PPAR agonists

What are they?

Substances that act upon the peroxisome proliferator activated receptor.

What is their use?

Their Pharmacokinetics is targeted mainly to the treatment of metabolic syndrome, triglycerides reduction, blood sugar reduction and insulin sensitivity improvement.

Why would someone want to use these class of substances?

Well, first let’s look at the health benefits:

  • insulin sensitivity
  • Triglyceride modulation
  • Lipoprotein modulation
  • Inflammation control
  • All that lead to enhanced cardiovascular efficiency and health and also exhibit anti-cancer properties (dose dependent)

Performance/appearance benefits.

  • Increased endurance
  • Increased strength-stamina
  • Increased recuperation ability
  • Increased fat catabolism (fat burning)
  • Depending on which peroxisome proliferator activator receptor it binds to, it exhibits muscle building properties.

Any side effects?

Well, there was a study done by GSK stating that the PPARδ Agonist used could have cancer proliferation effects but the study was totally flawed in the essence that they used humongous dosages for a very prolonged period of time (1 year straight).

To put this into perspective, an average 70kg male would be taking 65-75mg per day of the PPARδ Agonist used in the study for a year straight! That would be beyond illogical and naive.

A sane and safe dosing protocol is 10-20mg/day, 4-5 days/week for 8 weeks with at least 12 weeks off the substance.

We do hope that we’ve put this fear-mongering theory to rest.

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